The 2016 Ghana Malaria Indicator Survey (2016 GMIS) was implemented by the Ghana Statistical Service (GSS), in close collaboration with the Ghana National Malaria Control Programme (NMCP), and the National Public Health Reference Laboratory (NPHRL) of the Ghana Health Service. The survey used a nationally representative sample of 200 clusters and about 6000 households. The primary objective of the 2016 GMIS is to provide current estimates of key malaria indicators. Specific objectives were: To measure the extent of ownership and use of mosquito bednets To assess coverage of intermittent preventive treatment to protect pregnant women To identify practices and specific medications used for treating malaria among children under age 5 To measure indicators of behaviour change communication messages, knowledge, and practices about malaria To measure the prevalence of malaria and anaemia among children age 6-59 months The findings from the 2016 GMIS will assist policy makers and program managers in evaluating and designing programs and strategies for improving malaria control interventions in Ghana.