The documented dataset covers Enterprise Survey (ES) panel data collected in Paraguay in 2006, 2010 and 2017, as part of Latin America and the Caribbean Enterprise Surveys rollout, an initiative of the World Bank. The objective of the study is to obtain feedback from enterprises in client countries on the state of the private sector as well as to help in building a panel of enterprise data that will make it possible to track changes in the business environment over time, thus allowing, for example, impact assessments of reforms. Through face-to-face interviews with firms in the manufacturing and services sectors, the survey assesses the constraints to private sector growth and creates statistically significant business environment indicators that are comparable across countries. Enterprise Surveys target a sample consisting of longitudinal (panel) observations and new cross-sectional data. Panel firms are prioritized in the sample selection, comprising up to 50% of the sample. For all panel firms, regardless of the sample, current eligibility or operating status is determined and included in panel datasets. Paraguay ES 2010 was conducted in June 2010 and April 2011, Paraguay ES 2006 was carried out in March and October 2006. Stratified random sampling was used to select the surveyed businesses. Data was collected using face-to-face interviews. Data from 1,338 establishments was analyzed: 460 businesses were from 2006 only, 153 from 2010 only, 246 from 2017 only, 110 firms were from 2010 and 2017, 180 from 2006 and 2010, 186 firms were from 2006, 2010 and 2017. The standard Enterprise Survey topics include firm characteristics, gender participation, access to finance, annual sales, costs of inputs and labor, workforce composition, bribery, licensing, infrastructure, trade, crime, competition, capacity utilization, land and permits, taxation, informality, business-government relations, innovation and technology, and performance measures. Over 90 percent of the questions objectively measure characteristics of a country’s business environment. The remaining questions assess the survey respondents’ opinions on what are the obstacles to firm growth and performance.